InnateDB Protein
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IDBP-7708.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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JOSD1
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Protein Name
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Josephin domain containing 1
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Synonyms
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dJ508I15.2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000216039
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InnateDB Gene
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IDBG-7706 (JOSD1)
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Protein Structure
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Function |
Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. {ECO:0000269PubMed:21118805, ECO:0000269PubMed:23625928}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:23625928}. Cytoplasm {ECO:0000269PubMed:23625928}. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008242
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omega peptidase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006155
Machado-Joseph disease protein MJD
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PFAM |
PF02099
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PRINTS |
PR01233
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15040
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PhosphoSite |
PhosphoSite-Q15040
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TrEMBL |
B0QY58
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UniProt Splice Variant |
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Entrez Gene |
9929
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UniGene |
Hs.704191
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RefSeq |
NP_055691
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HUGO |
HGNC:28953
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OMIM |
615323
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CCDS |
CCDS13976
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HPRD |
08823
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IMGT |
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EMBL |
AK291827
AL021707
BC015026
CH471095
CR456473
D31884
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GenPept |
AAH15026
BAA06682
BAF84516
CAB42863
CAG30359
EAW60259
EAW60260
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