InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZSWIM2

Summary

InnateDB Protein

IDBP-77132.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZSWIM2

Protein Name

zinc finger, SWIM-type containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295131

InnateDB Gene

IDBG-77130 (ZSWIM2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0043621	protein self-association

Biological Process

GO:0000209	protein polyubiquitination
GO:0006915	apoptotic process
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors