Homo sapiens Protein: TOMM34
Summary
InnateDB Protein IDBP-77135.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOMM34
Protein Name translocase of outer mitochondrial membrane 34
Synonyms HTOM34P; TOM34; URCC3;
Species Homo sapiens
Ensembl Protein ENSP00000361900
InnateDB Gene IDBG-77133 (TOMM34)
Protein Structure
UniProt Annotation
Function Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. {ECO:0000269PubMed:10101285, ECO:0000269PubMed:11913975, ECO:0000269PubMed:9324309}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10101285}. Mitochondrion outer membrane {ECO:0000269PubMed:10101285}; Peripheral membrane protein {ECO:0000269PubMed:10101285}; Cytoplasmic side {ECO:0000269PubMed:10101285}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031072 heat shock protein binding
Biological Process
GO:0006626 protein targeting to mitochondrion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat
PFAM PF00515
PF07719
PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15785
PhosphoSite PhosphoSite-Q15785
TrEMBL
UniProt Splice Variant
Entrez Gene 10953
UniGene Hs.517066
RefSeq NP_006800
HUGO HGNC:15746
OMIM
CCDS CCDS13340
HPRD 11641
IMGT
EMBL AB085681 AK222952 AL109839 BC001763 BC007423 BC014907 BT020008 BT020009 CH471077 CR456765 U58970
GenPept AAC64484 AAH01763 AAH07423 AAH14907 AAV38811 AAV38812 BAD96672 BAF32949 CAB89422 CAG33046 EAW75886