InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: H2AFY2

Summary

InnateDB Protein

IDBP-77202.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2AFY2

Protein Name

H2A histone family, member Y2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362352

InnateDB Gene

IDBG-77200 (H2AFY2)

Protein Structure

UniProt Annotation

Function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. {ECO:0000269PubMed:15621527}.

Subcellular Localization

Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0031490	chromatin DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006334	nucleosome assembly
GO:0007420	brain development
GO:0007549	dosage compensation
GO:0016568	chromatin modification
GO:0045814	negative regulation of gene expression, epigenetic
GO:0071169	establishment of protein localization to chromatin
GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter

Cellular Component

GO:0000786	nucleosome
GO:0000790	nuclear chromatin
GO:0001740	Barr body
GO:0005634	nucleus
GO:0035098	ESC/E(Z) complex
GO:0070062	extracellular vesicular exosome