Version 5.4
Homo sapiens Protein: SAR1A
Summary
InnateDB Protein IDBP-77273.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAR1A
Protein Name SAR1 homolog A (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362336
InnateDB Gene IDBG-77267 (SAR1A)
Protein Structure
UniProt Annotation
Function Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). {ECO:0000250, ECO:0000269PubMed:17005010}.
Subcellular Localization Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR006689 Small GTPase superfamily, ARF/SAR type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00025
PRINTS PR00328
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9NR31
TrEMBL X1WI22
UniProt Splice Variant
Entrez Gene 56681
UniGene Hs.628284
RefSeq
HUGO HGNC:10534
OMIM 607691
CCDS
HPRD 07608
IMGT
EMBL AL731540
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca