Version 5.4
Homo sapiens Protein: SEMG1
Summary
InnateDB Protein IDBP-77304.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMG1
Protein Name semenogelin I
Synonyms CT103; dJ172H20.2; SEMG; SGI;
Species Homo sapiens
Ensembl Protein ENSP00000361867
InnateDB Gene IDBG-77302 (SEMG1)
Protein Structure
UniProt Annotation
Function Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. {ECO:0000269PubMed:19889947}.Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. {ECO:0000269PubMed:19889947}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Seminal vesicle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0007320 insemination
GO:0019953 sexual reproduction
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0030141 secretory granule
Protein Structure and Domains
PDB ID
InterPro IPR008836 Semenogelin
PFAM PF05474
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04279
PhosphoSite PhosphoSite-P04279
TrEMBL Q6Y808
UniProt Splice Variant
Entrez Gene 6406
UniGene Hs.1968
RefSeq NP_002998
HUGO HGNC:10742
OMIM 182140
CCDS CCDS13345
HPRD 01641
IMGT
EMBL AL049767 AY174423 AY174424 AY174437 AY174446 AY256465 AY256466 AY256467 AY256468 AY256469 BC007096 BC055416 BT007177 CH471077 J04440 M81650 Z47556
GenPept AAA18168 AAB59506 AAH07096 AAH55416 AAO20112 AAO20113 AAO20126 AAO20127 AAP35841 AAP82462 AAP82463 AAP82464 AAP82465 AAP82466 CAA87636 CAB53523 EAW75871

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca