InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPFFR1

Summary

InnateDB Protein

IDBP-77358.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPFFR1

Protein Name

neuropeptide FF receptor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000277942

InnateDB Gene

IDBG-77356 (NPFFR1)

Protein Structure

UniProt Annotation

Function

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008188	neuropeptide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0008150	biological_process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR005395 Neuropeptide FF receptor family
IPR005396 Neuropeptide FF receptor, type 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01012
PR01570
PR01571

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9GZQ6