Version 5.4
Homo sapiens Protein: OSGEPL1
Summary
InnateDB Protein IDBP-77373.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSGEPL1
Protein Name O-sialoglycoprotein endopeptidase-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264151
InnateDB Gene IDBG-77371 (OSGEPL1)
Protein Structure
UniProt Annotation
Function Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. {ECO:0000255HAMAP-Rule:MF_03179}.
Subcellular Localization Mitochondrion {ECO:0000255HAMAP- Rule:MF_03179, ECO:0000269PubMed:19694617}.
Disease Associations
Tissue Specificity Widely expressed, with maximum expression in pituitary gland, prostate, rectum and uterus. {ECO:0000269PubMed:19694617}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0070526 threonylcarbamoyladenosine biosynthetic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR000905 Gcp-like domain
IPR017861 Kae1/YgjD family
PFAM PF00814
PRINTS PR00789
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H4B0
PhosphoSite PhosphoSite-Q9H4B0
TrEMBL E7EVL7
UniProt Splice Variant
Entrez Gene 64172
UniGene Hs.645448
RefSeq NP_071748
HUGO HGNC:23075
OMIM
CCDS CCDS46472
HPRD 07026
IMGT
EMBL AC013468 AJ295148 AK055441 BC011904
GenPept AAH11904 AAY14771 BAB70923 CAC14666

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca