Version 5.4
Homo sapiens Protein: ORMDL1
Summary
InnateDB Protein IDBP-77386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORMDL1
Protein Name ORM1-like 1 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000326869
InnateDB Gene IDBG-77384 (ORMDL1)
Protein Structure
UniProt Annotation
Function Negative regulator of sphingolipid synthesis. {ECO:0000269PubMed:20182505}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:12093374}; Multi-pass membrane protein {ECO:0000269PubMed:12093374}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. Expressed at intermediate level in pancreas, placenta and brain but low in skeletal muscle and lung. {ECO:0000269PubMed:12093374}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006672 ceramide metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007203 ORMDL
PFAM PF04061
PRINTS
PIRSF PIRSF018147
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P0S3
PhosphoSite PhosphoSite-Q9P0S3
TrEMBL F6WST4
UniProt Splice Variant
Entrez Gene 94101
UniGene Hs.700632
RefSeq
HUGO HGNC:16036
OMIM 610073
CCDS CCDS2301
HPRD 15092
IMGT
EMBL AB064959 AB064960 AC013468 AF151036 AF395701 AF395702 AF395704 AK074756 AK075160 AK313533 BC005200 CH471058 CR936635
GenPept AAF36122 AAH05200 AAM43502 AAM43503 AAY14772 BAC11184 BAC11441 BAC11710 BAC11711 BAG36310 CAI56776 EAX10887 EAX10888 EAX10889

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca