InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HABP4

Summary

InnateDB Protein

IDBP-77406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HABP4

Protein Name

hyaluronan binding protein 4

Synonyms

IHABP-4; IHABP4; Ki-1/57; SERBP1L;

Species

Homo sapiens

Ensembl Protein

ENSP00000364400

InnateDB Gene

IDBG-77404 (HABP4)

Protein Structure

UniProt Annotation

Function

May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription. {ECO:0000269PubMed:14699138, ECO:0000269PubMed:16455055}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Transported into the nuclear compartment in activated leukocytes.

Disease Associations

Tissue Specificity

Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes. {ECO:0000269PubMed:12505151, ECO:0000269PubMed:9523163}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002576	platelet degranulation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0043392	negative regulation of DNA binding
GO:0071260	cellular response to mechanical stimulus