InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NODAL

Summary

InnateDB Protein

IDBP-77434.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NODAL

Protein Name

nodal homolog (mouse)

Synonyms

HTX5;

Species

Homo sapiens

Ensembl Protein

ENSP00000287139

InnateDB Gene

IDBG-77432 (NODAL)

Protein Structure

UniProt Annotation

Function

Essential for mesoderm formation and axial patterning during embryonic development. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Heterotaxy, visceral, 5, autosomal (HTX5) [MIM:270100]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. HTX5 clinical features include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncus communis, and dextrocardia. {ECO:0000269PubMed:19064609, ECO:0000269PubMed:9354794}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0016015	morphogen activity
GO:0048018	receptor agonist activity
GO:0070698	type I activin receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001702	gastrulation with mouth forming second
GO:0001707	mesoderm formation
GO:0001829	trophectodermal cell differentiation
GO:0001831	trophectodermal cellular morphogenesis
GO:0001842	neural fold formation
GO:0001889	liver development
GO:0001890	placenta development
GO:0001892	embryonic placenta development
GO:0001893	maternal placenta development
GO:0001944	vasculature development
GO:0001947	heart looping
GO:0002085	inhibition of neuroepithelial cell differentiation
GO:0007368	determination of left/right symmetry
GO:0007369	gastrulation
GO:0007399	nervous system development
GO:0007420	brain development
GO:0007492	endoderm development
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0009948	anterior/posterior axis specification
GO:0009952	anterior/posterior pattern specification
GO:0009966	regulation of signal transduction
GO:0010085	polarity specification of proximal/distal axis
GO:0010470	regulation of gastrulation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016477	cell migration
GO:0019827	stem cell maintenance
GO:0022409	positive regulation of cell-cell adhesion
GO:0030324	lung development
GO:0032927	positive regulation of activin receptor signaling pathway
GO:0033505	floor plate morphogenesis
GO:0035050	embryonic heart tube development
GO:0035987	endodermal cell differentiation
GO:0038092	nodal signaling pathway
GO:0040007	growth
GO:0042074	cell migration involved in gastrulation
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045165	cell fate commitment
GO:0045596	negative regulation of cell differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048327	axial mesodermal cell fate specification
GO:0048382	mesendoderm development
GO:0048546	digestive tract morphogenesis
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048729	tissue morphogenesis
GO:0048859	formation of anatomical boundary
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0055123	digestive system development
GO:0060136	embryonic process involved in female pregnancy
GO:0060137	maternal process involved in parturition
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0060395	SMAD protein signal transduction
GO:0060460	left lung morphogenesis
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0060802	epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090009	primitive streak formation
GO:0090010	transforming growth factor beta receptor signaling pathway involved in primitive streak formation
GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1901164	negative regulation of trophoblast cell migration
GO:1901383	negative regulation of chorionic trophoblast cell proliferation
GO:2000036	regulation of stem cell maintenance