InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SGPL1

Summary

InnateDB Protein

IDBP-77513.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SGPL1

Protein Name

sphingosine-1-phosphate lyase 1

Synonyms

S1PL; SPL;

Species

Homo sapiens

Ensembl Protein

ENSP00000362298

InnateDB Gene

IDBG-77509 (SGPL1)

Protein Structure

UniProt Annotation

Function

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269PubMed:11018465, ECO:0000269PubMed:14570870, ECO:0000269PubMed:24809814}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Disease Associations

Tissue Specificity

Found in liver and kidney. {ECO:0000269PubMed:11018465}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008117	sphinganine-1-phosphate aldolase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0001553	luteinization
GO:0001570	vasculogenesis
GO:0001822	kidney development
GO:0006631	fatty acid metabolic process
GO:0006665	sphingolipid metabolic process
GO:0006672	ceramide metabolic process
GO:0006807	nitrogen compound metabolic process
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0008585	female gonad development
GO:0009058	biosynthetic process
GO:0009791	post-embryonic development
GO:0010761	fibroblast migration
GO:0019752	carboxylic acid metabolic process
GO:0030097	hemopoiesis
GO:0030148	sphingolipid biosynthetic process
GO:0030149	sphingolipid catabolic process
GO:0033327	Leydig cell differentiation
GO:0040014	regulation of multicellular organism growth
GO:0044281	small molecule metabolic process
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048705	skeletal system morphogenesis
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0030176	integral component of endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000192 Aminotransferase class V domain
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00266
PF00282
PF00155

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95470

PhosphoSite