Version 5.4
Homo sapiens Protein: TMEFF2
Summary
InnateDB Protein IDBP-77713.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEFF2
Protein Name transmembrane protein with EGF-like and two follistatin-like domains 2
Synonyms CT120.2; HPP1; TENB2; TPEF; TR;
Species Homo sapiens
Ensembl Protein ENSP00000272771
InnateDB Gene IDBG-77711 (TMEFF2)
Protein Structure
UniProt Annotation
Function May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. {ECO:0000269PubMed:10903839, ECO:0000269PubMed:17942404}.
Subcellular Localization Isoform 1: Membrane {ECO:0000305}; Single- pass type I membrane protein {ECO:0000305}.Isoform 2: Membrane {ECO:0000305}; Single- pass type I membrane protein {ECO:0000305}.Isoform 3: Secreted.
Disease Associations
Tissue Specificity Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. {ECO:0000269PubMed:10903839, ECO:0000269PubMed:10987305, ECO:0000269PubMed:11120884, ECO:0000269PubMed:11668495, ECO:0000269PubMed:16439095, ECO:0000269PubMed:16805794}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005576 extracellular region
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
IPR002350 Kazal domain
PFAM PF00008
PF00050
PF07648
PRINTS
PIRSF
SMART SM00181
SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UIK5
PhosphoSite PhosphoSite-Q9UIK5
TrEMBL
UniProt Splice Variant
Entrez Gene 23671
UniGene Hs.144513
RefSeq NP_057276
HUGO HGNC:11867
OMIM 605734
CCDS CCDS2314
HPRD 05760
IMGT
EMBL AB004064 AB017269 AC092644 AC098617 AF179274 AF242221 AF242222 AF264150 AK074507 AK222691 AL157430 AY358907 BC008973 CR457390 DQ133599
GenPept AAD55776 AAF91397 AAG49451 AAG49452 AAH08973 AAQ89266 AAX88893 AAY14874 AAZ43216 BAA87897 BAA90820 BAC11030 BAD96411 CAB75654 CAG33671

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca