Version 5.4
| Homo sapiens Protein: SPINLW1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-77846.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | SPINLW1 | ||||||||
| Protein Name | serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin) | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000361746 | ||||||||
| InnateDB Gene | IDBG-77844 (SPINLW1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. {ECO:0000269PubMed:15229136, ECO:0000269PubMed:17644992}. | ||||||||
| Subcellular Localization | Isoform 1: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells. {ECO:0000269PubMed:11404006, ECO:0000269PubMed:21461566}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR002223
Proteinase inhibitor I2, Kunitz metazoa IPR008197 Whey acidic protein-type 4-disulphide core |
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| PFAM |
PF00014
PF00095 |
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| PRINTS |
PR00759
PR00003 |
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| PIRSF | |||||||||
| SMART |
SM00131
SM00217 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | O95925 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 57119 | ||||||||
| UniGene | Hs.634667 | ||||||||
| RefSeq | NP_065131 | ||||||||
| HUGO | HGNC:15932 | ||||||||
| OMIM | 609031 | ||||||||
| CCDS | CCDS13359 | ||||||||
| HPRD | 10615 | ||||||||
| IMGT | |||||||||
| EMBL | AF286368 AF286369 AF286370 AK301937 AL031663 AL118493 BC044829 BC053369 | ||||||||
| GenPept | AAG00546 AAG00547 AAG00548 AAH44829 AAH53369 BAG63357 CAB37635 CAB56343 CAC36265 CAO03536 | ||||||||