InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SF3B1

Summary

InnateDB Protein

IDBP-77904.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SF3B1

Protein Name

splicing factor 3b, subunit 1, 155kDa

Synonyms

Hsh155; MDS; PRP10; PRPF10; SAP155; SF3b155;

Species

Homo sapiens

Ensembl Protein

ENSP00000335321

InnateDB Gene

IDBG-77902 (SF3B1)

Protein Structure

UniProt Annotation

Function

Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

Subcellular Localization

Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 171 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	171 [view]
Protein-Protein	168 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0000398	mRNA splicing, via spliceosome
GO:0008380	RNA splicing
GO:0009952	anterior/posterior pattern specification
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005689	U12-type spliceosomal complex
GO:0016607	nuclear speck
GO:0043231	intracellular membrane-bounded organelle
GO:0071013	catalytic step 2 spliceosome