Version 5.4
Homo sapiens Protein: TYW5
Summary
InnateDB Protein IDBP-78169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYW5
Protein Name tRNA-yW synthesizing protein 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000346627
InnateDB Gene IDBG-78167 (TYW5)
Protein Structure
UniProt Annotation
Function tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. {ECO:0000269PubMed:20739293}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0005506 iron ion binding
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0042803 protein homodimerization activity
Biological Process
GO:0031591 wybutosine biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR003347 JmjC domain
PFAM PF02373
PF08007
PRINTS
PIRSF
SMART SM00558
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2RUC4
PhosphoSite PhosphoSite-A2RUC4
TrEMBL A0A024R403
UniProt Splice Variant
Entrez Gene 129450
UniGene Hs.688597
RefSeq NP_001034782
HUGO HGNC:26754
OMIM
CCDS CCDS42795
HPRD 08232
IMGT
EMBL AC097717 AK095272 AK298977 BC063502 BC132835 BC136837 CH471063
GenPept AAH63502 AAI32836 AAI36838 AAY24162 BAC04517 BAG61071 EAW70191 EAW70194

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca