InnateDB Protein
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IDBP-78274.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TBC1D2
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Protein Name
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TBC1 domain family, member 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364207
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InnateDB Gene
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IDBG-78272 (TBC1D2)
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Protein Structure
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Function |
Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269PubMed:20116244}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:20116244}. Cytoplasmic vesicle {ECO:0000269PubMed:20116244}. Cell junction {ECO:0000269PubMed:20116244}.
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Disease Associations |
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Tissue Specificity |
Expressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level). {ECO:0000269PubMed:11785977, ECO:0000269PubMed:20116244}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000195
Rab-GTPase-TBC domain
IPR001849
Pleckstrin homology domain
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PFAM |
PF00566
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00164
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BYX2
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PhosphoSite |
PhosphoSite-Q9BYX2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55357
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UniGene |
Hs.371016
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RefSeq |
NP_060891
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HUGO |
HGNC:18026
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OMIM |
609871
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CCDS |
CCDS35080
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HPRD |
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IMGT |
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EMBL |
AB209721
AB449882
AF318370
AK026105
AK124772
AK298575
AL137073
AL353935
AL360081
AL591502
AY026527
BC028918
BC071978
CH471105
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GenPept |
AAH28918
AAH71978
AAK07684
AAL55877
BAB15361
BAD92958
BAG54093
BAG60767
BAH16625
CAB89247
CAH71887
CAI12580
CAI13885
CAI13894
EAW58882
EAW58884
EAW58887
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