Version 5.4
Homo sapiens Protein: TBC1D2
Summary
InnateDB Protein IDBP-78278.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBC1D2
Protein Name TBC1 domain family, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364205
InnateDB Gene IDBG-78272 (TBC1D2)
Protein Structure
UniProt Annotation
Function Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269PubMed:20116244}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:20116244}. Cytoplasmic vesicle {ECO:0000269PubMed:20116244}. Cell junction {ECO:0000269PubMed:20116244}.
Disease Associations
Tissue Specificity Expressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level). {ECO:0000269PubMed:11785977, ECO:0000269PubMed:20116244}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0045296 cadherin binding
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR000195 Rab-GTPase-TBC domain
IPR001849 Pleckstrin homology domain
PFAM PF00566
PF00169
PRINTS
PIRSF
SMART SM00164
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BYX2
PhosphoSite PhosphoSite-Q9BYX2
TrEMBL
UniProt Splice Variant
Entrez Gene 55357
UniGene Hs.371016
RefSeq
HUGO HGNC:18026
OMIM 609871
CCDS
HPRD
IMGT
EMBL AB209721 AB449882 AF318370 AK026105 AK124772 AK298575 AL137073 AL353935 AL360081 AL591502 AY026527 BC028918 BC071978 CH471105
GenPept AAH28918 AAH71978 AAK07684 AAL55877 BAB15361 BAD92958 BAG54093 BAG60767 BAH16625 CAB89247 CAH71887 CAI12580 CAI13885 CAI13894 EAW58882 EAW58884 EAW58887

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca