InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ORC2

Summary

InnateDB Protein

IDBP-78350.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ORC2

Protein Name

origin recognition complex, subunit 2

Synonyms

ORC2L;

Species

Homo sapiens

Ensembl Protein

ENSP00000234296

InnateDB Gene

IDBG-78348 (ORC2)

Protein Structure

UniProt Annotation

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin- mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269PubMed:22427655, ECO:0000269PubMed:22935713}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	69 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003688	DNA replication origin binding
GO:0005515	protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006270	DNA replication initiation

Cellular Component

GO:0000785	chromatin
GO:0000792	heterochromatin
GO:0000808	origin recognition complex
GO:0000939	condensed chromosome inner kinetochore
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005664	nuclear origin of replication recognition complex
GO:0005886	plasma membrane
GO:0016020	membrane