InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANXA7

Summary

InnateDB Protein

IDBP-78373.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA7

Protein Name

annexin A7

Synonyms

ANX7; SNX; SYNEXIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000362010

InnateDB Gene

IDBG-78371 (ANXA7)

Protein Structure

UniProt Annotation

Function

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta. {ECO:0000269PubMed:1825209}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	213 [view]
Protein-Protein	212 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0044822	poly(A) RNA binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0006914	autophagy
GO:0007599	hemostasis
GO:0008283	cell proliferation
GO:0008360	regulation of cell shape
GO:0009651	response to salt stress
GO:0009992	cellular water homeostasis
GO:0010629	negative regulation of gene expression
GO:0014070	response to organic cyclic compound
GO:0030855	epithelial cell differentiation
GO:0035176	social behavior
GO:0051592	response to calcium ion
GO:0061025	membrane fusion

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031982	vesicle
GO:0042584	chromaffin granule membrane
GO:0070062	extracellular vesicular exosome