InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CFLAR

Summary

InnateDB Protein

IDBP-78388.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFLAR

Protein Name

CASP8 and FADD-like apoptosis regulator

Synonyms

c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT;

Species

Homo sapiens

Ensembl Protein

ENSP00000312455

InnateDB Gene

IDBG-78386 (CFLAR)

Protein Structure

UniProt Annotation

Function

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269PubMed:9880531}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	63 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004197	cysteine-type endopeptidase activity
GO:0005123	death receptor binding
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008234	cysteine-type peptidase activity
GO:0032403	protein complex binding
GO:0035877	death effector domain binding

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007519	skeletal muscle tissue development
GO:0014732	skeletal muscle atrophy
GO:0014842	regulation of satellite cell proliferation
GO:0014866	skeletal myofibril assembly
GO:0016032	viral process
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043403	skeletal muscle tissue regeneration
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060544	regulation of necroptotic process
GO:0097190	apoptotic signaling pathway
GO:1901740	negative regulation of myoblast fusion
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031264	death-inducing signaling complex
GO:0031265	CD95 death-inducing signaling complex
GO:0045121	membrane raft
GO:0097342	ripoptosome

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001875 Death effector domain
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF01335
PF00656

PRINTS

PR00376

PIRSF

SMART

SM00031
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt