InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU3F4

Summary

InnateDB Protein

IDBP-78411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU3F4

Protein Name

POU class 3 homeobox 4

Synonyms

BRAIN-4; BRN-4; BRN4; DFN3; DFNX2; OCT-9; OTF-9; OTF9;

Species

Homo sapiens

Ensembl Protein

ENSP00000362296

InnateDB Gene

IDBG-78409 (POU3F4)

Protein Structure

UniProt Annotation

Function

Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.

Subcellular Localization

Nucleus.

Disease Associations

Deafness, X-linked, 2 (DFNX2) [MIM:304400]: A form of deafness characterized by both conductive hearing loss resulting from stapes (perilymphatic gusher) fixation, and progressive sensorineural deafness. {ECO:0000269PubMed:7581392, ECO:0000269PubMed:7839145, ECO:0000269PubMed:9298820, ECO:0000269PubMed:9778298}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Brain specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003680	AT DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007605	sensory perception of sound
GO:0021879	forebrain neuron differentiation
GO:0048839	inner ear development
GO:0090103	cochlea morphogenesis
GO:2001054	negative regulation of mesenchymal cell apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000327 POU-specific
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013847 POU domain
IPR016362 Transcription factor, homeobox/POU

PFAM

PF00157
PF00046
PF13413

PRINTS

PR00028

PIRSF

PIRSF002629

SMART

SM00352
SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References