InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF711

Summary

InnateDB Protein

IDBP-78524.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF711

Protein Name

zinc finger protein 711

Synonyms

CMPX1; dJ75N13.1; MRX97; Zfp711; ZNF4; ZNF5; ZNF6;

Species

Homo sapiens

Ensembl Protein

ENSP00000353922

InnateDB Gene

IDBG-78522 (ZNF711)

Protein Structure

UniProt Annotation

Function

Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C. {ECO:0000269PubMed:20346720}.

Subcellular Localization

Nucleus {ECO:0000305PubMed:20346720}.

Disease Associations

Mental retardation, X-linked, ZNF711-related (MRXZ) [MIM:300803]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:19377476}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in neural tissues. {ECO:0000269PubMed:20346720}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006794 Transcriptional activator, Zfx / Zfy domain
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR022755 Zinc finger, double-stranded RNA binding

PFAM

PF04704
PF00096
PF12171

PRINTS

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y462