InnateDB Protein
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IDBP-78628.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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STX17
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Protein Name
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syntaxin 17
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000259400
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InnateDB Gene
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IDBG-78626 (STX17)
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Protein Structure
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Function |
SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). {ECO:0000269PubMed:21545355, ECO:0000269PubMed:23217709}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to the mitochondria according to PubMed:23217709. A significant amount is also present in the cytosol.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000727
Target SNARE coiled-coil domain
IPR010989
t-SNARE
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PFAM |
PF05739
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PRINTS |
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PIRSF |
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SMART |
SM00397
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TIGRFAMs |
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Modification |
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SwissProt |
P56962
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PhosphoSite |
PhosphoSite-P56962
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TrEMBL |
E9PJW1
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UniProt Splice Variant |
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Entrez Gene |
55014
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UniGene |
Hs.704031
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RefSeq |
NP_060389
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HUGO |
HGNC:11432
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OMIM |
604204
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CCDS |
CCDS6745
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HPRD |
05013
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IMGT |
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EMBL |
AK000658
AL358937
BC101564
BC101566
CH471105
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GenPept |
AAI01565
AAI01567
BAA91311
CAI95318
EAW58920
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