InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERP44

Summary

InnateDB Protein

IDBP-78641.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERP44

Protein Name

endoplasmic reticulum protein 44

Synonyms

PDIA10; TXNDC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000262455

InnateDB Gene

IDBG-78639 (ERP44)

Protein Structure

UniProt Annotation

Function

Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. {ECO:0000269PubMed:11847130, ECO:0000269PubMed:14517240}.

Subcellular Localization

Endoplasmic reticulum lumen.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006457	protein folding
GO:0006986	response to unfolded protein
GO:0009100	glycoprotein metabolic process
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis

Cellular Component

GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0009986	cell surface
GO:0070062	extracellular vesicular exosome