InnateDB Protein
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IDBP-7867.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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APOBEC3A
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Protein Name
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apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000249116
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InnateDB Gene
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IDBG-7865 (APOBEC3A)
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Protein Structure
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Function |
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269PubMed:10469298, ECO:0000269PubMed:12859895, ECO:0000269PubMed:16527742, ECO:0000269PubMed:19461882, ECO:0000269PubMed:20062055, ECO:0000269PubMed:20615867, ECO:0000269PubMed:21123384, ECO:0000269PubMed:21368204, ECO:0000269PubMed:21460793, ECO:0000269PubMed:21496894, ECO:0000269PubMed:22457529, ECO:0000269PubMed:22896697}.
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Subcellular Localization |
Nucleus. Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. {ECO:0000269PubMed:11863358, ECO:0000269PubMed:16527742, ECO:0000269PubMed:20062055, ECO:0000269PubMed:20308164}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007904
APOBEC-like, C-terminal
IPR013158
APOBEC-like, N-terminal
IPR016193
Cytidine deaminase-like
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PFAM |
PF05240
PF08210
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P31941
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PhosphoSite |
PhosphoSite-P31941
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
200315
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UniGene |
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RefSeq |
NP_663745
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HUGO |
HGNC:17343
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OMIM |
607109
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CCDS |
CCDS13981
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HPRD |
06168
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IMGT |
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EMBL |
AL022318
BC126416
CR456393
U03891
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GenPept |
AAA03706
AAI26417
CAG30279
CAI17897
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