InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLHL4

Summary

InnateDB Protein

IDBP-78716.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLHL4

Protein Name

kelch-like 4 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362211

InnateDB Gene

IDBG-78714 (KLHL4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Expressed in adult fibroblasts and in a range of fetal tissues including tongue, palate, and mandible.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9C0H6