InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Park2

Summary

InnateDB Protein

IDBP-787567.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Park2

Protein Name

Parkinson disease (autosomal recessive, juvenile) 2, parkin

Synonyms

PRKN;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000140587

InnateDB Gene

IDBG-136351 (Park2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 124 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	124 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0030165	PDZ domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0043130	ubiquitin binding
GO:0051087	chaperone binding
GO:0061630	ubiquitin protein ligase activity
GO:1990381	ubiquitin-specific protease binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0000422	mitochondrion degradation
GO:0001933	negative regulation of protein phosphorylation
GO:0001963	synaptic transmission, dopaminergic
GO:0001964	startle response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006513	protein monoubiquitination
GO:0007612	learning
GO:0007626	locomotory behavior
GO:0008219	cell death
GO:0008344	adult locomotory behavior
GO:0010506	regulation of autophagy
GO:0016567	protein ubiquitination
GO:0019538	protein metabolic process
GO:0032232	negative regulation of actin filament bundle assembly
GO:0033132	negative regulation of glucokinase activity
GO:0035249	synaptic transmission, glutamatergic
GO:0042415	norepinephrine metabolic process
GO:0042417	dopamine metabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0044257	cellular protein catabolic process
GO:0046676	negative regulation of insulin secretion
GO:0046928	regulation of neurotransmitter secretion
GO:0050804	regulation of synaptic transmission
GO:0051583	dopamine uptake involved in synaptic transmission
GO:0051865	protein autoubiquitination
GO:0060548	negative regulation of cell death
GO:0070534	protein K63-linked ubiquitination
GO:0070842	aggresome assembly
GO:0070936	protein K48-linked ubiquitination
GO:0070997	neuron death
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:1901215	negative regulation of neuron death
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0016235	aggresome
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1355296

InterPro

IPR000626 Ubiquitin-like
IPR002867 Zinc finger, C6HC-type
IPR003977 E3 ubiquitin-protein ligase parkin
IPR019956 Ubiquitin
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00240
PF14560
PF01485
PF11976

PRINTS

PR01475
PR00348

PIRSF

PIRSF037880

SMART

SM00213
SM00647

TIGRFAMs

Post-translational Modifications

Modification

Cross-References