InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab27a

Summary

InnateDB Protein

IDBP-787776.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab27a

Protein Name

RAB27A, member RAS oncogene family

Synonyms

2210402C08Rik; 2410003M20Rik; 4933437C11Rik; ash;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000139310

InnateDB Gene

IDBG-184264 (Rab27a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0031489	myosin V binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006605	protein targeting
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030318	melanocyte differentiation
GO:0032400	melanosome localization
GO:0032402	melanosome transport
GO:0043316	cytotoxic T cell degranulation
GO:0043320	natural killer cell degranulation
GO:0043473	pigmentation
GO:0051875	pigment granule localization
GO:0051904	pigment granule transport

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005622	intracellular
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016020	membrane
GO:0030141	secretory granule
GO:0042470	melanosome

Protein Structure and Domains

PDB ID

MGI:1861441

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt