Version 5.4
Mus musculus Protein: Sos2
Summary
InnateDB Protein IDBP-787847.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sos2
Protein Name son of sevenless homolog 2 (Drosophila)
Synonyms mSOS-2; SOS-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000138589
InnateDB Gene IDBG-144636 (Sos2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0032318 regulation of Ras GTPase activity
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043087 regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID MGI:98355
InterPro IPR000219 Dbl homology (DH) domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001849 Pleckstrin homology domain
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR007125 Histone core
IPR009072 Histone-fold
IPR023578 Ras guanine nucleotide exchange factor, domain
PFAM PF00621
PF00618
PF00169
PF00617
PF00125
PRINTS
PIRSF
SMART SM00325
SM00229
SM00233
SM00147
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL S4R2C4
UniProt Splice Variant
Entrez Gene 20663
UniGene
RefSeq
MGI ID
MGI Symbol Sos2
OMIM
CCDS
HPRD
IMGT
EMBL AC133949 AC141560 AC153658 AH008384
GenPept AAF08010

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca