InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PABPC5

Summary

InnateDB Protein

IDBP-78807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PABPC5

Protein Name

poly(A) binding protein, cytoplasmic 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000308012

InnateDB Gene

IDBG-78803 (PABPC5)

Protein Structure

UniProt Annotation

Function

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.Isoform 2: Mitochondrion matrix {ECO:0000269PubMed:23275553}. Note=Co-fractionates with mtDNA and co-immunoprecipitates with the mitochondrial poly(A) polymerase.

Disease Associations

Tissue Specificity

Expressed in fetal brain and in a range of adult tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

Biological Process

Cellular Component

GO:0005759

mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR003954 RNA recognition motif domain, eukaryote
IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4

PFAM

PF00076

PRINTS

PIRSF

SMART

SM00360
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96DU9