InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FZD7

Summary

InnateDB Protein

IDBP-78810.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD7

Protein Name

frizzled family receptor 7

Synonyms

FzE3;

Species

Homo sapiens

Ensembl Protein

ENSP00000286201

InnateDB Gene

IDBG-78808 (FZD7)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0006355	regulation of transcription, DNA-templated
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0008406	gonad development
GO:0010812	negative regulation of cell-substrate adhesion
GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0019827	stem cell maintenance
GO:0030182	neuron differentiation
GO:0033077	T cell differentiation in thymus
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035412	regulation of catenin import into nucleus
GO:0035567	non-canonical Wnt signaling pathway
GO:0038031	non-canonical Wnt signaling pathway via JNK cascade
GO:0042327	positive regulation of phosphorylation
GO:0042666	negative regulation of ectodermal cell fate specification
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046330	positive regulation of JNK cascade
GO:0048103	somatic stem cell division
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0060070	canonical Wnt signaling pathway
GO:0060231	mesenchymal to epithelial transition
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032589	neuron projection membrane
GO:0045177	apical part of cell