Version 5.4
Mus musculus Protein: Mef2a
Summary
InnateDB Protein IDBP-788231.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mef2a
Protein Name myocyte enhancer factor 2A
Synonyms A430079H05Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000138566
InnateDB Gene IDBG-192076 (Mef2a)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085 RNA polymerase II transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0033613 activating transcription factor binding
GO:0035035 histone acetyltransferase binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007399 nervous system development
GO:0007507 heart development
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048311 mitochondrion distribution
GO:0055005 ventricular cardiac myofibril assembly
GO:0061337 cardiac conduction
GO:0070375 ERK5 cascade
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:99532
InterPro IPR002100 Transcription factor, MADS-box
IPR022102 Holliday junction regulator protein family C-terminal
PFAM PF00319
PF12347
PRINTS PR00404
PIRSF
SMART SM00432
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60929
PhosphoSite PhosphoSite-Q60929
TrEMBL D3Z6M5
UniProt Splice Variant
Entrez Gene 17258
UniGene
RefSeq
MGI ID
MGI Symbol Mef2a
OMIM
CCDS CCDS39981
HPRD
IMGT
EMBL AC120123 AC158751 AK132678 BC061128 BC096598 U30823
GenPept AAA74030 AAH61128 AAH96598 BAE21297

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca