InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp8

Summary

InnateDB Protein

IDBP-788282.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp8

Protein Name

caspase 8

Synonyms

CASP-8; FLICE; MACH; Mch5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000140546

InnateDB Gene

IDBG-157464 (Casp8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	135 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004175	endopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0031625	ubiquitin protein ligase binding
GO:0035877	death effector domain binding
GO:0046982	protein heterodimerization activity
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process

Biological Process

GO:0001525	angiogenesis
GO:0001841	neural tube formation
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007507	heart development
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0009409	response to cold
GO:0030225	macrophage differentiation
GO:0032025	response to cobalt ion
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0034612	response to tumor necrosis factor
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045471	response to ethanol
GO:0045651	positive regulation of macrophage differentiation
GO:0045862	positive regulation of proteolysis
GO:0046677	response to antibiotic
GO:0048738	cardiac muscle tissue development
GO:0051291	protein heterooligomerization
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0060546	negative regulation of necroptotic process
GO:0070243	regulation of thymocyte apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097194	execution phase of apoptosis
GO:0097284	hepatocyte apoptotic process
GO:2001233	regulation of apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0030690	Noc1p-Noc2p complex
GO:0031265	CD95 death-inducing signaling complex
GO:0043005	neuron projection
GO:0044297	cell body
GO:0045121	membrane raft
GO:0097342	ripoptosome

Protein Structure and Domains

PDB ID

MGI:1261423

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001875 Death effector domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF01335
PF00656

PRINTS

PR00376

PIRSF

SMART

SM00031
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt