Version 5.4
Mus musculus Protein: Il6st
Summary
InnateDB Protein IDBP-788501.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il6st
Protein Name interleukin 6 signal transducer
Synonyms 5133400A03Rik; AA389424; BB405851; CD130; D13Ertd699e; gp130;
Species Mus musculus
Ensembl Protein ENSMUSP00000139311
InnateDB Gene IDBG-182517 (Il6st)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004915 interleukin-6 receptor activity
GO:0004921 interleukin-11 receptor activity
GO:0004923 leukemia inhibitory factor receptor activity
GO:0004924 oncostatin-M receptor activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005138 interleukin-6 receptor binding
GO:0005515 protein binding
GO:0019970 interleukin-11 binding
GO:0019981 interleukin-6 binding
Biological Process
GO:0005977 glycogen metabolic process
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0008593 regulation of Notch signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0038154 interleukin-11-mediated signaling pathway
GO:0038165 oncostatin-M-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045669 positive regulation of osteoblast differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0048861 leukemia inhibitory factor signaling pathway
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005896 interleukin-6 receptor complex
GO:0005900 oncostatin-M receptor complex
GO:0009897 external side of plasma membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0070110 ciliary neurotrophic factor receptor complex
Protein Structure and Domains
PDB ID MGI:96560
InterPro IPR003961 Fibronectin, type III
IPR010457 Immunoglobulin C2-set-like, ligand-binding
IPR015321 Interleukin-6 receptor alpha, binding
PFAM PF00041
PF01108
PF06328
PF09240
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL V9GXT4
UniProt Splice Variant
Entrez Gene 16195
UniGene
RefSeq
MGI ID
MGI Symbol Il6st
OMIM
CCDS
HPRD
IMGT
EMBL AC159196 AK170020
GenPept BAE41514

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca