InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOP58

Summary

InnateDB Protein

IDBP-78854.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOP58

Protein Name

NOP58 ribonucleoprotein homolog (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264279

InnateDB Gene

IDBG-78852 (NOP58)

Protein Structure

UniProt Annotation

Function

Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. {ECO:0000250, ECO:0000269PubMed:15574333, ECO:0000269PubMed:17636026, ECO:0000269PubMed:19620283}.

Subcellular Localization

Nucleus, nucleolus. Nucleus, nucleoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.

Experimentally validated
Total	71 [view]
Protein-Protein	71 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030515	snoRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006364	rRNA processing
GO:0006608	snRNP protein import into nucleus
GO:0016049	cell growth

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005732	small nucleolar ribonucleoprotein complex
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0016020	membrane
GO:0031428	box C/D snoRNP complex
GO:0070761	pre-snoRNP complex