InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALDOB

Summary

InnateDB Protein

IDBP-78996.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDOB

Protein Name

aldolase B, fructose-bisphosphate

Synonyms

ALDB; ALDO2;

Species

Homo sapiens

Ensembl Protein

ENSP00000363988

InnateDB Gene

IDBG-78994 (ALDOB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269PubMed:18000879}.

Disease Associations

Hereditary fructose intolerance (HFI) [MIM:229600]: Autosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life. {ECO:0000269PubMed:10024431, ECO:0000269PubMed:10970798, ECO:0000269PubMed:12205126, ECO:0000269PubMed:15532022, ECO:0000269PubMed:15880727, ECO:0000269PubMed:1967768, ECO:0000269PubMed:2336380, ECO:0000269PubMed:3383242, ECO:0000269PubMed:8162030, ECO:0000269PubMed:8299883}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004332	fructose-bisphosphate aldolase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0042802	identical protein binding
GO:0051117	ATPase binding
GO:0070061	fructose binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006000	fructose metabolic process
GO:0006001	fructose catabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006116	NADH oxidation
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0032781	positive regulation of ATPase activity
GO:0044281	small molecule metabolic process
GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly