InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDH22

Summary

InnateDB Protein

IDBP-79001.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDH22

Protein Name

cadherin 22, type 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361336

InnateDB Gene

IDBG-78999 (CDH22)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0007156

homophilic cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000233 Cadherin, cytoplasmic domain
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR016196 Major facilitator superfamily domain, general substrate transporter

PFAM

PF01049
PF00028

PRINTS

PR00205

PIRSF

SMART

SM00112

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt