InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plscr1

Summary

InnateDB Protein

IDBP-790042.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plscr1

Protein Name

phospholipid scramblase 1

Synonyms

MmTRA1a; MmTRA1b; Nor1; Tra1; Tra1a; Tra1b; Tras1; Tras2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000139479

InnateDB Gene

IDBG-191069 (Plscr1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0005154	epidermal growth factor receptor binding
GO:0005509	calcium ion binding
GO:0017124	SH3 domain binding
GO:0017128	phospholipid scramblase activity
GO:0042609	CD4 receptor binding

Biological Process

GO:0006659	phosphatidylserine biosynthetic process
GO:0006953	acute-phase response
GO:0017121	phospholipid scrambling
GO:0030099	myeloid cell differentiation
GO:0032091	negative regulation of protein binding
GO:0033003	regulation of mast cell activation
GO:0035455	response to interferon-alpha
GO:0043065	positive regulation of apoptotic process
GO:0045071	negative regulation of viral genome replication
GO:0045089	positive regulation of innate immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070782	phosphatidylserine exposure on apoptotic cell surface
GO:0071222	cellular response to lipopolysaccharide
GO:0071345	cellular response to cytokine stimulus
GO:0097193	intrinsic apoptotic signaling pathway
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0031012	extracellular matrix
GO:0045121	membrane raft