Version 5.4
Mus musculus Protein: Cacna1c
Summary
InnateDB Protein IDBP-790569.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacna1c
Protein Name calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms Cav1.2; Cchl1a1; D930026N18Rik; MBC; MELC-CC;
Species Mus musculus
Ensembl Protein ENSMUSP00000140056
InnateDB Gene IDBG-182003 (Cacna1c)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006939 smooth muscle contraction
GO:0007268 synaptic transmission
GO:0007628 adult walking behavior
GO:0008217 regulation of blood pressure
GO:0008542 visual learning
GO:0017156 calcium ion-dependent exocytosis
GO:0019229 regulation of vasoconstriction
GO:0030073 insulin secretion
GO:0030252 growth hormone secretion
GO:0034765 regulation of ion transmembrane transport
GO:0042593 glucose homeostasis
GO:0046620 regulation of organ growth
GO:0055085 transmembrane transport
GO:0060083 smooth muscle contraction involved in micturition
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0002095 caveolar macromolecular signaling complex
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
Protein Structure and Domains
PDB ID MGI:103013
InterPro IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunit
IPR005451 Voltage-dependent calcium channel, L-type, alpha-1C subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
PFAM PF00520
PF08016
PF08763
PRINTS PR00167
PR01630
PR01635
PIRSF
SMART SM01062
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q0PCR6
UniProt Splice Variant
Entrez Gene 12288
UniGene
RefSeq NP_033911
MGI ID
MGI Symbol Cacna1c
OMIM
CCDS
HPRD
IMGT
EMBL AB259049 AC036121 AC127328
GenPept BAF03165

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca