InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VARS

Summary

InnateDB Protein

IDBP-79179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VARS

Protein Name

valyl-tRNA synthetase

Synonyms

G7A; VARS1; VARS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000364815

InnateDB Gene

IDBG-79175 (VARS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0002161	aminoacyl-tRNA editing activity
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004832	valine-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006438	valyl-tRNA aminoacylation
GO:0006450	regulation of translational fidelity
GO:0010467	gene expression

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002300 Aminoacyl-tRNA synthetase, class Ia
IPR002303 Valine-tRNA ligase
IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR010978 tRNA-binding arm
IPR010987 Glutathione S-transferase, C-terminal-like
IPR013155 Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR015413 Methionyl/Leucyl tRNA synthetase

PFAM