Version 5.4
Homo sapiens Protein: OCSTAMP
Summary
InnateDB Protein IDBP-79286.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OCSTAMP
Protein Name chromosome 20 open reading frame 123
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000279028
InnateDB Gene IDBG-79284 (OCSTAMP)
Protein Structure
UniProt Annotation
Function Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0034241 positive regulation of macrophage fusion
GO:0045672 positive regulation of osteoclast differentiation
GO:0071356 cellular response to tumor necrosis factor
GO:0071391 cellular response to estrogen stimulus
GO:0072674 multinuclear osteoclast differentiation
GO:0090290 positive regulation of osteoclast proliferation
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR012858 Dendritic cell-specific transmembrane protein-like
PFAM PF07782
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BR26
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 128506
UniGene Hs.526636
RefSeq NP_542452
HUGO HGNC:16116
OMIM
CCDS CCDS54468
HPRD
IMGT
EMBL AL034424 AL935075 AL935089 BX281477
GenPept CAC36102

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca