InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TP53RK

Summary

InnateDB Protein

IDBP-79382.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP53RK

Protein Name

TP53 regulating kinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361186

InnateDB Gene

IDBG-79380 (TP53RK)

Protein Structure

UniProt Annotation

Function

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. {ECO:0000250, ECO:0000269PubMed:11546806}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:22912744}.

Disease Associations

Tissue Specificity

Highly expressed in testis. Weakly expressed in heart kidney and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	37 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0016787	hydrolase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0008033	tRNA processing
GO:0009103	lipopolysaccharide biosynthetic process
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR018934 RIO-like kinase
IPR022495 Serine/threonine-protein kinase Bud32

PFAM

PF00069
PF07714
PF06293
PF01163

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt