InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAM23

Summary

InnateDB Protein

IDBP-79484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAM23

Protein Name

ADAM metallopeptidase domain 23

Synonyms

MDC-3; MDC3;

Species

Homo sapiens

Ensembl Protein

ENSP00000264377

InnateDB Gene

IDBG-79482 (ADAM23)

Protein Structure

UniProt Annotation

Function

May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform Gamma: Secreted.

Disease Associations

Tissue Specificity

Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole. {ECO:0000269PubMed:14697522}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0007417	central nervous system development

Cellular Component

GO:0005576	extracellular region
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt