InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EHMT2

Summary

InnateDB Protein

IDBP-79495.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EHMT2

Protein Name

euchromatic histone-lysine N-methyltransferase 2

Synonyms

BAT8; C6orf30; G9A; GAT8; KMT1C; NG36;

Species

Homo sapiens

Ensembl Protein

ENSP00000364678

InnateDB Gene

IDBG-79489 (EHMT2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	117 [view]
Protein-Protein	113 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)
GO:0046976	histone methyltransferase activity (H3-K27 specific)
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006275	regulation of DNA replication
GO:0006306	DNA methylation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007130	synaptonemal complex assembly
GO:0007281	germ cell development
GO:0007286	spermatid development
GO:0009566	fertilization
GO:0010424	DNA methylation on cytosine within a CG sequence
GO:0016571	histone methylation
GO:0034968	histone lysine methylation
GO:0035265	organ growth
GO:0045087	innate immune response (InnateDB)
GO:0051567	histone H3-K9 methylation
GO:0070734	histone H3-K27 methylation

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome

Protein Structure and Domains

PDB ID

InterPro

IPR001214 SET domain
IPR002110 Ankyrin repeat
IPR003606 Pre-SET zinc-binding sub-group
IPR007728 Pre-SET domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00856
PF00023
PF13606
PF05033
PF11929
PF12796

PRINTS

PR01415

PIRSF

SMART

SM00317
SM00248
SM00468

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt