InnateDB Protein
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IDBP-79498.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CENPI
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Protein Name
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centromere protein I
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Synonyms
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CENP-I; FSHPRH1; LRPR1; Mis6;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362018
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InnateDB Gene
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IDBG-79496 (CENPI)
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Protein Structure
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Function |
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269PubMed:12640463, ECO:0000269PubMed:16622420}.
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Subcellular Localization |
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR012485
Centromere protein I
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PFAM |
PF07778
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q92674
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PhosphoSite |
PhosphoSite-Q92674
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TrEMBL |
Q5JX02
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UniProt Splice Variant |
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Entrez Gene |
2491
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UniGene |
Hs.348920
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RefSeq |
XP_005262168
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HUGO |
HGNC:3968
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OMIM |
300065
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CCDS |
CCDS14479
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HPRD |
02089
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IMGT |
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EMBL |
AL109963
BC012462
CH471115
X97249
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GenPept |
AAH12462
CAA65884
CAB72340
CAI42268
EAX02841
EAX02842
EAX02843
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