InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLC1

Summary

InnateDB Protein

IDBP-7956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLC1

Protein Name

deleted in liver cancer 1

Synonyms

ARHGAP7; HP; p122-RhoGAP; STARD12;

Species

Homo sapiens

Ensembl Protein

ENSP00000276297

InnateDB Gene

IDBG-7954 (DLC1)

Protein Structure

UniProt Annotation

Function

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. {ECO:0000269PubMed:18786931, ECO:0000269PubMed:19170769, ECO:0000269PubMed:19710422}.

Subcellular Localization

Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.

Disease Associations

Tissue Specificity

Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0042169	SH2 domain binding

Biological Process

GO:0001843	neural tube closure
GO:0003007	heart morphogenesis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0021575	hindbrain morphogenesis
GO:0030036	actin cytoskeleton organization
GO:0030336	negative regulation of cell migration
GO:0030900	forebrain development
GO:0032321	positive regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035307	positive regulation of protein dephosphorylation
GO:0048041	focal adhesion assembly
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051497	negative regulation of stress fiber assembly
GO:1900119	positive regulation of execution phase of apoptosis