InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF7L

Summary

InnateDB Protein

IDBP-79570.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF7L

Protein Name

TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000320283

InnateDB Gene

IDBG-79564 (TAF7L)

Protein Structure

UniProt Annotation

Function

Probably functions as a spermatogensis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Cytoplasmic in spermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates into the nuclei of pachytene spermatocytes and round spermatids. {ECO:0000250}.

Disease Associations

Tissue Specificity

Testis-specific. {ECO:0000269PubMed:11279525}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0008150	biological_process
GO:0030154	cell differentiation