InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FZD5

Summary

InnateDB Protein

IDBP-79674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD5

Protein Name

frizzled family receptor 5

Synonyms

C2orf31; HFZ5;

Species

Homo sapiens

Ensembl Protein

ENSP00000354607

InnateDB Gene

IDBG-79672 (FZD5)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. {ECO:0000269PubMed:10097073}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane and also found at the Golgi. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0019901	protein kinase binding
GO:0030165	PDZ domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0000578	embryonic axis specification
GO:0001525	angiogenesis
GO:0001944	vasculature development
GO:0006915	apoptotic process
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0008595	anterior/posterior axis specification, embryo
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0031076	embryonic camera-type eye development
GO:0031077	post-embryonic camera-type eye development
GO:0032729	positive regulation of interferon-gamma production
GO:0033077	T cell differentiation in thymus
GO:0043507	positive regulation of JUN kinase activity
GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0060061	Spemann organizer formation
GO:0060070	canonical Wnt signaling pathway
GO:0060561	apoptotic process involved in morphogenesis
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0060716	labyrinthine layer blood vessel development
GO:0060718	chorionic trophoblast cell differentiation
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0071219	cellular response to molecule of bacterial origin
GO:1901382	regulation of chorionic trophoblast cell proliferation
GO:2000810	regulation of tight junction assembly

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0042995	cell projection
GO:0048471	perinuclear region of cytoplasm