Version 5.4
Homo sapiens Protein: PTH2R
Summary
InnateDB Protein IDBP-79784.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTH2R
Protein Name parathyroid hormone 2 receptor
Synonyms PTHR2;
Species Homo sapiens
Ensembl Protein ENSP00000272847
InnateDB Gene IDBG-79782 (PTH2R)
Protein Structure
UniProt Annotation
Function This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed abundantly in brain and pancreas. Also expressed in the testis. {ECO:0000269PubMed:7797535}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004991 parathyroid hormone receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000832 GPCR, family 2, secretin-like
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR017981 GPCR, family 2-like
PFAM PF00002
PF02793
PRINTS PR00249
PIRSF
SMART SM00008
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49190
PhosphoSite PhosphoSite-P49190
TrEMBL Q53T35
UniProt Splice Variant
Entrez Gene 5746
UniGene Hs.580599
RefSeq NP_005039
HUGO HGNC:9609
OMIM 601469
CCDS CCDS2383
HPRD 03276
IMGT
EMBL AC012362 AC019185 AH006647 AK294181 AY497546 BC036811 U25128 U47124
GenPept AAA96796 AAC50157 AAC50767 AAH36811 AAR90849 AAY14871 AAY15091 BAG57499

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca